Author: Michael Couper
Couper, Michael, 2025 Advancements and Areas of Need in Paediatric Liver disease, Intestinal and Pancreatic Transplantation, Flinders University, College of Medicine and Public Health
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This thesis examines advancements and ongoing needs in paediatric liver, intestinal, and pancreatic transplantation. It comprises nine publications, including seven main papers and two appendices structured into three sections:
Novel Aetiologies: This section discusses new diagnostic entities, such as a post-COVID acute liver disease in children, a genetic liver disease with unique management needs, and a rare tumour involving the liver, gastrointestinal tract, and pancreas.
Areas of Need and Further Research: This section covers drug-induced liver disease (DILI), biliary disease, and neonatal liver disease, highlighting areas for improved diagnosis and treatment.
New and Emerging Management Strategies: This section presents new techniques like bedside ultrasound for rejection monitoring in intestinal transplant patients and explores outcomes of multi-transplant procedures and islet cell transplantation (TP-IAT) for hereditary pancreatitis.
Overall, the thesis explores diagnostic advancements, emerging diseases, and innovative management strategies in paediatric hepatology and transplantation.
Keywords: Paediatric, Liver disease, Liver transplantation, Intestinal transplantation, Pancreatic transplantation
Subject: Medicine thesis
Thesis type: Doctor of Philosophy
Completed: 2025
School: College of Medicine and Public Health
Supervisor: Scott Morris