Author: Joseph Douglas Builth-Williams
Builth-Williams, Joseph Douglas, 2013 Dynamical (e,2e) Studies of Bio-Molecules, Flinders University, School of Chemical and Physical Sciences
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As the basis of life, deoxyribonucleic acid (DNA) is an extremely important molecule and though, in many ways, it is a stable molecule, even the slightest damage can lead to potentially disastrous results. One such source of damage is high-energy ionising radiation and while this high-energy radiation can cause significant damage by directly interacting with DNA, a significant amount of damage is also caused by the low-energy secondary electrons it generates through ionisation. Previous attempts to model the effects of ionising radiation on DNA have been limited by the experimental data available at the time, and so have used water as a model for the biological medium. Thus a need to understand how these secondary ionising species, in particular electrons, interact with biomolecules exists. In this thesis I report on original relative Triple Differential Cross Section (TDCS) measurements for the electron impact ionisation of pyrimidine, α-tetrahydrofurfuryl alcohol, tetrahydrofuran, tetrahydropyran and 1,4-dioxane. The TDCSs provide the probability that a bio-molecule will eject an additional electron, of a particular energy and at a particular angle, after being struck by an incident electron (that is subsequently scattered from the target molecule, at a specific angle and energy). In each case the Highest Occupied Molecular Orbital (HOMO) was probed, specifically the 7b_2, 28a, 9b+12a', 15a' and 8a_g orbitals for each respective molecule listed above. In addition, some measurements were also made on the 10a_1 orbital of pyrimidine. Furthermore, all these TDCS measurements are compared to results from calculations using the Molecular Three-Body Distorted Wave (M3DW) model. Fair agreement is typically found between the M3DW results and the experimental data. All the present results were measured using coplanar asymmetric kinematics.
Keywords: e2e,THF,THP,tetrahydrofuran,tetrahydropyran,dioxane,pyrimidine,TDCS,triple differential cross section,biomolecule,biomolecules,low-energy secondary electrons,radiation,DNA,deoxyribonucleic acid,electron interaction,ionisation,Molecular Three-Body Distorted Wave,M3DW
Subject: Physics thesis
Thesis type: Masters
School: School of Chemical and Physical Sciences
Supervisor: Michael J. Brunger